What is use of closantel?
Closantel is used primarily in cattle and sheep for the treatment and control of adult and immature liver flukes, haematophagous nematodes and larval stages of some arthropods. Dosages. Closantel may be administered to sheep and cattle orally or parenterally via drench, bolus or injectable formulations.
What is closantel sodium?
Closantel is a synthetic anti parasitic agent which is highly effective against adults and larvae (6 to weeks old) of liver flukes (Fasciola hepatica), and against several important gastrointestinal roundworms (e.g. Bunostomum, Haemonchus, Oesophagostomum, Ostertagia – Teladorsagia, Strongyloides, Trichostrongylus), as …
Is Closantel pregnancy safe?
Hypersensitivity to closantel. Do not use for intravenous or intramuscular administration. Do not use in cattle or ewes producing milk for human consumption, including in the dry period. Do not use in the last trimester of pregnancy in heifers, which are intended to produce milk for human consumption.
Who makes moxidectin?
American Cyanamid Company
In the late 1980s, an American Cyanamid Company agronomist discovered the Streptomyces bacteria from which moxidectin is derived in a soil sample from Australia. Two companies filed patents for moxidectin: Glaxo Group and the American Cyanamid Company; in 1988, all patents were transferred to American Cyanamid.
Which is better ivermectin or moxidectin?
Moxidectin was moderately effective (62.6-79.1%) in removing encysted cyathostome late third stage larvae (LL3) and L4, whereas ivermectin was ineffective (0%) against these stages. By contrast, ivermectin was 95.4% effective against Gasterophilus spp. third instar stage, whereas moxidectin was only 0-20.4% effective.
How much moxidectin can I give my dog?
Dosing Information of Moxidectin for Dogs and Cats In dogs, oral moxidectin is dosed at 1.5 mcg per pound (3 mcg/kg) once monthly in dogs. In dogs, injectable moxidectin is dosed at 0.023 mg per pound (0.05 mg/kg) intramuscularly every 6 months.
Is moxidectin safe for dogs?
Moxidectin is safe for dogs in the correct dosage, but it can have significant side-effects. High doses that are able to cross the blood-brain barrier have a neurotoxic effect and untreated moxidectin poisoning can result in severe symptoms or death. Exposure can take place through ingestion or topical exposure.
Is ivermectin and moxidectin the same thing?
Moxidectin, a macrocyclic lactone like ivermectin, is approved and marketed worldwide as a treatment for internal and external parasites in wide variety of companion and farm animals. It is currently under investigation in human onchocerciasis.
Is moxidectin toxic to dogs?
What are side effects of moxidectin in dogs?
When used as directed in dogs, side effects are uncommon. If the product is eaten, side effects include depression, salivation, dilated pupils, incoordination, panting, and generalized muscle tremors. In dogs that are sensitive to milbemycin, coma and death are possible.
Can you use sheep wormer on dogs?
Ivermectin is a very commonly used wormer, suitable for horses, cattle, sheep, birds, and a wide range of small mammals. It is occasionally used in dogs – but never in collies and other herding breeds.
Is moxidectin the same as ivermectin?
What is the difference between ivermectin and moxidectin?
Can you give sheep drench to dogs?
Ivermectin (ivermectin) Sheep Drench has been formulated for use in sheep only. This product should not be used in other animal species as severe adverse reactions, including fatalities in dogs, may result.
Can you use sheep dewormer for dogs?
But do avoid letting any dog, of any breed, ingest dropped or unattended dewormers formulated for horses. “It’s safest to never use any large animal products in dogs,” she adds. “Use the dog product.”
Can you worm a dog with sheep wormer?
Drenches are one of the most common delivery forms of wormers for ruminants (i.e. cattle, sheep and goats), less frequent for pig, and rather scarce for poultry. They are also used for pets, more for cats and puppies than for dogs.
Can you buy ivermectin over the counter for dogs?
In the case of ivermectin specifically, the FDA said: “Ivermectin, like all macrocyclic lactone drugs indicated for heartworm prevention for dogs, are prescription only because a veterinarian’s expertise is necessary to ensure the safe and effective use of the drug.
Can I give my dog 3mg ivermectin?
Many dogs can tolerate doses of ivermectin up to 2,000 micrograms per kilogram but can overdose if more is mistakenly given. Just as the drug can kill parasites in small doses, it can poison dogs, causing a number of neurological symptoms.
What is Closantel used for in sheep?
Closantel provides sustained protection against the re-infestation by both mature and immature stages of barber’s pole worm in sheep for 4 weeks after dosing. Closantel controls both mature and immature stages of liver fluke as well as all stages of nasal bots.
Does WSD Closantel work on lambs?
WSD Closantel WSD CLOSANTEL SUSTAINED ACTION ORAL ANTHELMINTIC AND FLUKICIDE FOR SHEEP AND LAMBS contains Closantel (37.5 g/L), a member of the salicylanilide and substituted phenol family of drenches. WSD CLOSANTEL is effective against internal parasites sensitive to this family including the following parasites:
Can Closantel kill Barber’s pole worms in sheep?
If present in large numbers, barber’s pole worms can kill sheep. Closantel can provide control of susceptible barber’s pole worm, including sustained protection against re-infection. CLOSICARE PLUS SELENIUM protects sheep against closantel-susceptible strains of barber’s pole worm for 4 weeks (up to 99.9% efficacy at four weeks after drenching).
What is the LD50 of Closantel in rats?
Sheep: 1 mL product/5 kg bw, equivalent to 7.5 mg closantel /kg bw. LD50 (acute oral) in rats: for closantel a.i. 262 to 342 mg/kg (depending on the studies) Suspected poisoning? Read the article on closantel safety in this site. Withholding periods (=withdrawal times) for meat & milk (country-specific differences may apply: read the product label)