What is a Upec infection?
Uropathogenic Escherichia coli (UPEC) is a causative agent in the vast majority of urinary tract infections (UTIs), including cystitis and pyelonephritis, and infectious complications, which may result in acute renal failure in healthy individuals as well as in renal transplant patients.
What does Upec cause?
Strains of uropathogenic E. coli (UPEC) are the primary cause of urinary tract infections, including both cystitis and pyelonephritis. These bacteria have evolved a multitude of virulence factors and strategies that facilitate bacterial growth and persistence within the adverse settings of the host urinary tract.
How is Upec treated?
Among other antibiotics, imipenem represents the best efficient antibiotic against all UPEC strains (100%), followed by ertapenem (99.98%), amikacin (99.94%), and nitrofurantoin (99.91%).
What is Upec in E. coli?
UPEC are strains of Escherichia coli that divert from their commensal status as intestinal flora, grow and persist in the urinary tract and exhibit diverse array of virulence factors and strategies, which allow them to infect and cause diseases in the urinary tract.
Is E. coli same as UTI?
Infection of the bladder (cystitis). This type of UTI is usually caused by Escherichia coli (E. coli), a type of bacteria commonly found in the gastrointestinal (GI) tract. However, sometimes other bacteria are responsible. Sexual intercourse may lead to cystitis, but you don’t have to be sexually active to develop it.
What are the treatment options for urinary tract infection (UPEC)?
There are both direct and indirect strategies against UPEC infections. Direct strategies are targeting bacteria viability, bladder epithelium adhesion and biofilm formation; indirect strategies elicit and enhance immune responses, by stimulating infected tissues and cells to overreact to UPEC invasion.
What is the global transcription profile for UPEC during urinary tract infection?
These transcriptomics studies defined the global transcription profile for UPEC during UTI, highlighted the high genomic diversity of different UPEC strains, and confirmed, on a global scale, the expression during UTI of several genes encoding virulence factors.
Are UPEC persistent and resistant to antibiotics serious?
Despite clinical symptoms of UTIs have been ameliorated by numerous antibiotics, UPEC persistence and resistance to antibiotics represent a serious problem ( Blango and Mulvey, 2010 ).
What does UPEC resistance look like on a drug screen?
UPEC resistance is shown with a red background, susceptibility with a green background, whereas the yellow background shows antibiotics that already show resistance in some UPEC strains. Antibiotics will continue to be an unavoidable source for the prevention of UTIs on a case-by-case basis.