Is VCAM a selectin?
Soluble forms of E-selectin, ICAM-1 and VCAM-1 are present in the supernatants of cytokine activated cultured endothelial cells.
What does ICAM 1 stand for?
intercellular adhesion molecule
The intercellular adhesion molecule (ICAM) 1 is an Ig-like cell adhesion molecule expressed by several cell types, including leukocytes and endothelial cells.
What is ICAM inflammation?
Abstract. ICAM-1 is a cell surface glycoprotein and an adhesion receptor that is best known for regulating leukocyte recruitment from circulation to sites of inflammation.
What is VCAM 1 on blood test?
Vascular cell adhesion molecule-1 (VCAM-1) is one of the adhesion molecules that have been implicated as a mediator of angiogenesis[1]. As one of the cell adhesion molecules in the immunoglobulin superfamily, human VCAM-1 is Mr 100000-110000, type 1 transmembrane glycoprotein[2-4].
Are selectins cadherins?
Selectins (P, E, L) ; they contain lectin domain. Cadherins (E=epithelial, P=placental, N=neural subclasses)
Where are VCAM located?
VCAM-1 is located on the luminal surface and lateral surface of endothelial cells but not on the basal surface of endothelial cells.
What is ICAM immunology?
The intercellular adhesion molecule (ICAM) 1 is an Ig-like cell adhesion molecule expressed by several cell types, including leukocytes and endothelial cells.
What does VCAM stand for?
Vascular cell adhesion molecule
Vascular cell adhesion molecule (VCAM-1) is a cytokine-inducible surface molecule that mediates adhesion of various leukocyte types, such as lymphocytes, monocytes, and eosinophils.
What is VCAM in medicine?
vascular cell adhesion molecule-1.
What do selectins and integrins do?
Selectins and some of their counter-receptors function also as signal-transducing receptors, significantly contributing to leukocyte and endothelial cell activation. Integrins represent a large family of adhesion receptors that are widely expressed and mainly interact with extracellular matrix components.
What is VCAM-1 on blood test?
What is VCAM in immunology?
VCAM-1 is a key cell adhesion molecule involved in inflammation that is closely implicated in various immunological disorders, including rheumatoid arthritis, asthma, transplant rejection, and cancer (Table 1). VCAM-1 is a potential therapeutic target in immunological disorders and cancer.
Is VCAM an integrin?
The vascular cell adhesion molecule VCAM-1 was originally identified as a cytokine-inducible adhesion molecule on human endothelial cells, mediating the binding to leukocytes and melanoma cells (178,203,204). VCAM-1 is a ligand for the α4β1 integrin (VLA-4) and binds weakly to α4β7 (102,205–207).