What is hemoglobin C Harlem?
Hemoglobin CHarlem (Hb CH) is a new hemoglobin variant that migrates near the position of Hb C on electrophoresis at pH 8.6 and is associated with erythrocyte sickling and gelation and relative insolubility of the hemolysate upon deoxygenation.
What is hemoglobin HPLC test?
Hemoglobin (Hb) electrophoresis by HPLC is used to identify the different types of hemoglobin present in the blood. Hemoglobin is a protein present inside the red blood cells that functions to transport oxygen to the tissues and organs of the body.
What does hemoglobin C trait mean?
What is hemoglobin C trait? Hemoglobin C trait (AC) is an inherited condition which affects the hemoglobin in your red blood cells. • Hemoglobin is a protein in red blood cells. The job of hemoglobin is. to carry oxygen throughout the body.
Why is HPLC blood test done?
The HPLC blood test expanded as a High Performance Liquid Chromatography test, is performed to screen Thalassemias and Hemoglobinopathies. This test is performed by taking the sample mixture and separating it for further diagnosis in a medical laboratory.
What is the cost of HPLC test?
The cost of HPLC Test is Rs. 599 only.
What is the use of HPLC?
The purpose high performance liquid chromatography (HPLC) analysis of any drugs is to confirm the identity of a drug and provide quantitative results and also to monitor the progress of the therapy of a disease.
What results HPLC?
How do you get hemoglobin C disease?
Hemoglobin C disease affects the red blood cells. It occurs when a person inherits two copies of hemoglobin C from their parents. Usually , it requires no treatment. However, some people develop mild anemia and symptoms such as fatigue, weakness, and a fever.
What causes haemoglobin C?
Hemoglobin C is caused due to mutation in the beta-globin chain in which glutamate (acidic) is replaced by lysine (basic) in the sixth position of the beta-globin chain. This mutation makes Hb C less soluble than Hb A, forming hexagonal crystals (HbC crystals as seen in the peripheral smear).
What is hemoglobin C?
Enhancing Healthcare Team Outcomes Hemoglobin C is a benign hemoglobinopathy. It is caused due to mutation in the beta-globin chain of hemoglobin.
What is the epidemiology of hemoglobin C (HC) disease?
Epidemiology. However, it is possible for a person of any race or nationality to have hemoglobin C trait. In terms of geographic distribution, the hemoglobin C allele is found at the highest frequencies in West Africa, where it has been associated with protection against malaria. Hemoglobin C disease is present at birth,…
What is Hb C Harlem syndrome?
The double mutation is termed Hb C-Harlem (Hb C-Georgetown) because the abnormal hemoglobin migrates with Hb C on alkaline hemoglobin electrophoresis. Patients heterozygous for this anomaly are asymptomatic, but patients with compound heterozygosity for Hb S and Hb C-Harlem have crises similar to those with Hb SS disease. 84
What is the pathophysiology of hemoglobin C disease?
The anemia in hemoglobin C disease is classified as hemolytic, because it is caused by the destruction of red blood cells. An enlarged spleen, and sometimes jaundice, may also occur.