What is GRN163L?
GRN163L is a novel anti-cancer drug. It has been characterized preclinically and shown to inhibit telomerase in human tumor cells of many cancer types (including lung, breast, prostate, liver, and early stage of human breast cancer), in both cell culture systems and animal models.
How does imetelstat work?
Imetelstat binds with high affinity to the template region of the RNA component of telomerase, resulting in direct, competitive inhibition of telomerase enzymatic activity, rather than elicit its effect through an antisense inhibition of protein translation. Imetelstat is administered by intravenous infusion.
What is ALX148?
ALX148 (A) is a fusion protein comprised of a high affinity CD47 blocker linked to an inactive immunoglobulin Fc region.
How do you produce telomerase?
Here are the Four Strategies to Boost Telomerase Activity
- Eat a low inflammatory diet, which is low in bad fats, sodium and refined sugars.
- Exercise for at least 30 minutes of moderate intensity per day.
Is Magrolimab a checkpoint inhibitor?
Magrolimab is a potential, first-in-class investigational monoclonal antibody against CD47 and a macrophage checkpoint inhibitor that is designed to interfere with recognition of CD47 by the SIRPα receptor on macrophages, with the goal of blocking the “don’t eat me” signal used by cancer cells to avoid being ingested …
What is Evorpacept?
Evorpacept (formerly ALX 148) is an intravenously administered CD47 antigen inhibitors, being developed by ALX Oncology (formerly Alexo Therapeutics) for the treatment of solid tumours, myelodysplastic syndrome, breast cancer, acute myeloid leukemia, head and neck squamous cell carcinoma, gastric cancer and non- …
What is Magrolimab used for?
Magrolimab is a drug that targets a protein on the surface of tumor cells called CD47 and allows specialized immune cells, called macrophages, to destroy the tumor cells.
Is Magrolimab a chemo drug?
Magrolimab is a first-in-class anti-CD47 monoclonal antibody under development for several hematologic cancers, including myelodysplastic syndromes (MDS) and solid tumors, while Onureg is a chemotherapy treatment used in acute myeloid leukemia (AML), chronic myelomonocytic leukemia (CMML) and MDS.