How is angiomax supplied?
Angiomax is supplied as a sterile, lyophilized powder in single-dose, glass vials. Each vial contains 250 mg of bivalirudin equivalent to an average of 275 mg of bivalirudin trifluoroacetate*.
Is there a reversal agent for Angiomax?
Because there is no reversal agent or antidote for bivalirudin, adequate hemostasis will occur when bivalirudin has been metabolized sufficiently to allow for thrombin generation and clot formation.
What is angiomax infusion?
Angiomax is a direct thrombin inhibitor indicated for use as an anticoagulant. in patients undergoing percutaneous coronary intervention (PCI) including. patients with heparin-induced thrombocytopenia (HIT) or heparin-induced. thrombocytopenia and thrombosis syndrome (HITTS). (
Does angiomax affect act?
The affect of angiomax on activated clotting time (ACT) was found to be concentration dependent. However, the PK/PD (ACT) relationship was not similar between pediatrics and adults. Younger pediatrics, especially less than 6 months old were more sensitive to bivalirudin in terms of ACT.
How do you mix Angiomax?
Angiomax is intended for intravenous bolus injection and continuous infusion after reconstitution and dilution. To each 250 mg vial, add 5 mL of Sterile Water for Injection, USP. Gently swirl until all material is dissolved.
Is angiomax a platelet inhibitor?
or adjunctive therapy for PCI are aimed at inhibiting thrombin and platelet activity. The synthetic, direct thrombin inhibitor bivalirudin (Angiomax) is approved for use as an antithrombotic agent in patients undergoing PCI.
How do you dilute bivalirudin?
Bivalirudin should be initially reconstituted to give a solution of 50 mg/ml bivalirudin. Reconstituted material should then be further diluted in a total volume of 50 ml to give a solution of 5 mg/ml bivalirudin. Reconstituted and diluted product should be thoroughly mixed prior to administration.
How do you calculate Angiomax?
Angiomax is intended for intravenous bolus injection and continuous infusion after reconstitution and dilution….Instructions for Preparation and Administration.
| Weight (kg) | Using 5 mg/mL Concentration | |
|---|---|---|
| Bolus 0.75 mg/kg (mL) | Infusion 1.75 mg/kg/h (mL/h) | |
| 43-47 | 7 | 16 |
| 48-52 | 7.5 | 17.5 |
How do you administer bivalirudin?
The recommended dose of bivalirudin for patients undergoing PCI is an intravenous bolus of 0.75 mg/kg body weight followed immediately by an intravenous infusion at a rate of 1.75 mg/kg body weight/hour for at least the duration of the procedure.
What is the recommended dose of Angiomax for cardiac catheterization?
The recommended dose of Angiomax is an intravenous (IV) bolus dose of 0.75 mg/kg, followed immediately by an infusion of 1.75 mg/kg/h for the duration of the PCI/PTCA procedure.
How do you administer Angiomax?
The recommended dose of Angiomax is an intravenous bolus dose of 0.75 mg/kg, followed immediately by an infusion of 1.75 mg/kg/h for the duration of the procedure. Five minutes after the bolus dose has been administered, an activated clotting time (ACT) should be performed and an additional bolus of 0.3 mg/kg should be given if needed.
Should the bolus dose of Angiomax be reduced for renal impairment?
No reduction in the bolus dose is needed for any degree of renal impairment. The infusion dose of Angiomax may need to be reduced, and anticoagulant status monitored in patients with renal impairment. Patients with moderate renal impairment (30-59 mL/min) should receive an infusion of 1.75 mg/kg/h.
How much bivalirudin is in Angiomax?
Angiomax is supplied as a sterile white lyophilized cake, in single-dose vials. Each vial contains 250 mg bivalirudin, equivalent to an average of 275 mg of bivalirudin trifluoroacetate*, 125 mg mannitol, and sodium hydroxide to adjust the pH to 5-6 (equivalent of approximately 12.5 mg sodium).