Where does bladder cancer metastasize to first?

When bladder cancer spreads, it first invades the bladder wall, which is made up of four distinct layers. It can take some time for cancer to penetrate all of these layers, but once it has, it can then spread into the surrounding fatty tissues and lymph nodes.

What is the prognosis for transitional cell carcinoma?

The prognosis for any patient with metastatic or recurrent transitional cell cancer is poor. The proper management of recurrence depends on the sites of recurrence, extent of prior therapy, and individual patient considerations.

What is the main cause of transitional cell carcinoma?

working in the chemical or plastics industry. exposure to coal, tar, and asphalt. smoking. use of cancer treating drugs cyclophosphamide and ifosfamide.

Is transitional cell carcinoma aggressive?

Transitional Cell Carcinoma: An Aggressive Cancer This cancer may spread rapidly, affecting other organs and becoming life-threatening in some cases. Because of this, it’s especially important to know more about this disease and its symptoms, as well as your treatment options at Regional Cancer Care Associates.

How serious is transitional carcinoma?

High-grade TCC is the type of bladder cancer that is more likely to be life-threatening. Because transitional cells line many different parts of your urinary tract system, you can sometimes develop tumors in more than one place.

What bones does bladder cancer spread to?

Bone was the initial metastatic site for 25/48 patients (52.1%) and pain was the initial symptoms for 54.2% of patients. The most common locations were pelvis 64.6%, spine 58.3%, rib 20.8%, femur 12.5%, humerus 6.3% and clavicle 6.3%.

How serious is transitional cell carcinoma?

Transitional Cell Carcinoma: An Aggressive Cancer Transitional cell carcinoma affects the transitional cells of the urinary system and accounts for an overwhelming majority of bladder cancer diagnoses. This cancer may spread rapidly, affecting other organs and becoming life-threatening in some cases.

Where does transitional cell carcinoma metastasis?

Transitional cell carcinoma (TCC) of the bladder typically metastasizes to the pelvic lymph nodes and to visceral sites including the lungs, liver, and bones. Other sites include the brain, especially after systemic chemotherapy.

Where is bone pain with bladder cancer?

Bladder cancer can cause lower back pain when it reaches a more advanced form of the disease. The pain is typically only on one side of the back, but it can be centrally located. Lower back pain might occur once the tumors increase in size or cancer cells start to spread to other parts of your body.

Does bladder cancer cause joint pain?

Bone pain is a symptom that is experienced by some patients diagnosed with bladder cancer. Bone pain is not usually caused by bladder cancer, but it can potentially be a symptom of bladder cancer that is at a more advanced stage.

What are the symptoms of advanced bladder cancer?

Symptoms of Advanced Bladder Cancer

  • An inability to urinate.
  • Lower back pain on one side of the body.
  • Loss of appetite.
  • Unintended weight loss.
  • Overwhelming fatigue.
  • Bone pain.
  • Swelling in the feet.

How quickly does bladder cancer metastasize?

As many as 50% of patients with muscle-invasive bladder cancer may have occult metastases that become clinically apparent within 5 years of initial diagnosis and around 5% will have distant metastasis at the time of initial diagnosis. Most patients with overt metastatic disease die within 2 years despite chemotherapy.

Is stage 4 bladder cancer always terminal?

Metastatic bladder cancer is difficult to cure because it has already traveled to other parts of the body. The later you’re diagnosed and the farther the cancer has traveled, the less chance that your cancer will be cured. The 5-year survival rate is the rate of surviving for 5 years after a cancer diagnosis.

What are the signs that bladder cancer is getting worse?

A need to urinate more frequently than usual. Urinary urgency, even when the bladder is not full. A weak urine stream. A need to urinate many times during the night.

Why do feet swell with bladder cancer?

If cancer cells have spread to other organs or parts of the body, a person is diagnosed with metastatic bladder cancer. Bladder cancer that has metastasized (spread) to the lymph nodes, for example, can cause swelling in the feet.

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