Does ASCUS mean cervical cancer?

Squamous Cells of Undetermined Significance (ASCUS). This diagnosis does not mean that you have cervical cancer, but you have some mildly abnormal cellular changes. To determine if these results are benign reactive changes or early precancerous changes may require additional testing.

What is ASCUS of cervix?

A finding of abnormal cells in the tissue that lines the outer part of the cervix. ASCUS is the most common abnormal finding in a Pap test. It may be a sign of infection with certain types of human papillomavirus (HPV) or other types of infection, such as a yeast infection.

What is ASC-US diagnosis in cervical cancer?

An ASC-US diagnosis may mean NILM or true precancer and hence poses a management challenge, which needs to be addressed by triaging with molecular testing and histology. VIA (visual inspection with acetic acid), together with same-day treatment, has been shown to reduce the incidence of invasive cervical cancers.

Should older women with ascus be referred to colposcopic assessment?

It has been seen the women above the age of 30 years diagnosed with the ASCUS significantly predict the presence of high-risk HPV types. Hence, a strategy of limiting HPV testing in older women and referring those below 30 years for colposcopic assessment appears more effective [ 11 ].

When does the diagnosis of ASC-US begin to gain clinical significance?

The diagnosis of ASC-US begins to gain clinical significance when it is associated with a positive hrHPV diagnosis. Both reflex HPV DNA testing and co-testing have reported a high incidence of hrHPV in ASC-US specimens.

What is the clinical significance of ASC-US in squamous cell carcinoma?

It refers to abnormal cytologic changes that are suggestive of the squamous intraepithelial lesion (SIL) but are qualitatively and quantitatively less than those of a definitive SIL diagnosis.[1]  The clinical significance of ASC-US is based on the fact that this cytology finding is suggestive of a varying degree of SIL.

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