At which BCLC stages of HCC would ablation or surgery be an appropriate first line treatment option?

First, radiofrequency ablation (RFA) is recommended as first line option than surgical resection for BCLC 0 stage.

How the staging of HCC is done?

The BCLC system stratifies HCC patients based on tumor size, extent, liver function, and performance status. The BCLC staging system is thought to be better than other staging systems for determining prognosis, given the inclusion of liver function and performance status.

What is Stage C Livercancer?

Stage C (advanced stage) The cancer has grown into the large blood vessels in the liver or it has spread outside the liver to other parts of the body. It is causing symptoms. The Child-Pugh classification is A or B. The ECOG score is 1 or 2.

What is BCLC staging system?

One of these is the Barcelona Clinic Liver Cancer (BCLC) staging system. The BCLC looks at all of the following: the number and size of tumours in your liver. your general health and fitness – this is called your performance status or PS.

What is BCLC staging?

Barcelona clinic liver cancer (BCLC) staging uses a set of criteria to guide the management of patients with hepatocellular carcinoma (HCC). The classification takes the following variables into account 1,2: performance status (PS) Child-Pugh score.

How is metastatic HCC treated?

Treatment options for HCC are divided into surgical therapies (ie, resection, cryoablation, and liver transplantation) and nonsurgical therapies, which may be liver directed (ie, percutaneous ethanol injection, radiofrequency/microwave ablation, transarterial embolization, external beam radiation therapy) or systemic ( …

How fast does hepatocellular carcinoma grow?

The estimated time needed for a HCC to grow from 1 cm to 2 cm was 212 days in patients with HBV infection and 328 days in those with HCV infection.

What is PST in Bclc?

*PST-Performance Status Test.

How is Albi score calculated?

The formula for this scoring system relies on the following equation: ALBI score = (log10 bilirubin [µmol/L] × 0.66) + (albumin [g/L] × −0.0852). As a result, ALBI grades 1, 2, and 3 were developed as follows: ALBI score ≤ −2.60 (ALBI grade 1), > −2.60 to ≤ −1.39 (ALBI grade 2), and > −1.39 (ALBI grade 3).

When should I stop taking Nexavar?

Get medical help right away if you have any very serious side effects, including: chest/jaw/left arm pain, unusual sweating, fast/irregular heartbeat, severe dizziness, fainting, vomit that looks like coffee grounds, black/bloody stools, sudden/severe back pain or headache, weakness on one side of the body, sudden …

Is hepatocellular carcinoma a terminal?

Definition of terminal Hepatocellular Carcinoma Among HCC patients, 15–20% present with end stage or terminal stage HCC. Their median survival is less than 3–4 months. The pooled estimate of terminal stage HCC 1-year survival rate was 11% (95% CI, 4.7–22; range, 0–57%), in a meta analysis.

What is BCLC staging and treatment strategy in 2022?

Barcelona Clinic Liver Cancer (BCLC) staging and treatment strategy in 2022. The BCLC system establishes a prognosis in accordance with the five stages that are linked to first-line treatment recommendation. The expected outcome is expressed as median survival of each tumour stage according to the available scientific evidence.

What is BCLC staging for liver cancer?

Barcelona clinic liver cancer (BCLC) staging uses a set of criteria to guide management of patients with hepatocellular carcinoma (HCC).

What tests will be done during my treatment with Nexavar?

Your healthcare provider may do tests during your treatment with NEXAVAR to check the levels of potassium, magnesium, and calcium in your blood, and check the electrical activity of your heart with an electrocardiogram (ECG).

What scale does the BCLC staging system use?

The BCLC staging system uses the Eastern Cooperative Oncology Group (ECOG) scale: PS 2 – you are up and about more than half the day. You can look after yourself but can’t work

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