Is plasma concentration the same as serum concentration?
The expression ‘plasma concentration’ is often used in the literature, although serum samples have been taken. In most cases serum and plasma concentrations of analytes are the same. The choice depends mostly on the policy of the hospital or the availability of the test tubes in the ward.
How does plasma differ from serum?
Serum is the liquid that remains after the clotting of blood. Whereas, plasma is the liquid that remains when anticoagulant is added to prevent clotting. A transparent, straw-coloured, liquid portion of the blood. An undiluted fluid, the extracellular portion of blood.
What is the concentration of blood plasma?
Plasma contains 91% to 92% of water and 8% to 9% of solids. It mainly comprises of: Coagulants, mainly fibrinogen, aid in blood clotting. Plasma proteins, such as albumin and globulin, that help maintain the colloidal osmotic pressure at about 25 mmHg.
Why is plasma preferred over serum for many stat lab tests?
Faster turnaround of results is particularly vital for STAT testing, in which rapid decisions are necessary for critically ill patients. Additionally, plasma more accurately reflects the patient’s in-vivo state and provides a higher volume yield from the sample.
Why are drug concentrations more often measured in plasma rather than whole blood or serum?
Most drug concentrations are measured using plasma or serum that usually generate similar values. It is more relevant to use plasma or serum than whole blood measurements to estimate drug concentrations at the site of effect. However, some drugs, such as antimalarials, are extensively taken up by red blood cells.
How much serum is in 5 mL of blood?
1. Draw whole blood in an amount 2 1/2 times the required volume of serum so that a sufficient amount of serum can be obtained. The 5 mL red top tube will yield approximately 2.5 mL serum after clotting and centrifuging.
How is plasma concentration measured?
When measuring the drug concentration in plasma, a sample of whole blood is drawn from the patient (like cylinder on the left). The sample is then centrifuged to separate the RBC and plasma (like the cylinder on the right). The plasma is withdrawn and analyzed for drug concentration and the RBC is discarded.
Can plasma sample be used interchangeably with serum sample?
Plasma is stated to be the preferred sample for AST measurement in the WHO document. Serum and plasma results should not be used interchangeably (5).
What is the difference between serum and plasma quizlet?
What is the difference between serum and plasma? Plasma is the liquid portion of unclotted blood and still contains the clotting factors. Serum is the liquid portion of blood that has been allowed to clot.
Why is plasma used for drug concentration?
Plasma concentration monitoring of most antiarrhythmic agents is of value for certain specific purposes: to determine compliance to antiarrhythmic therapy, to detect and analyze possible drug interactions, to assess the benefit to risk ratio for increasing the dose of a particular antiarrhythmic agent, to maintain a …
Why drug concentration is measured in plasma?
Therefore, measuring the plasma concentration of a drug allows the doctor to track the dosage to the individual patient and to obtain the maximum therapeutic effect with minimal risk of toxicity. Information about plasma concentration is helpful for a number of drugs in clinical practice.
How is plasma converted to serum?
Plasma can be converted to serum by the method of defibrination. Coagulation factors present in plasma can be activated to form fibrin, with the addition of calcium chloride and thrombin (1). Thrombin cleaves fibrinogen to form fibrin monomers, which polymerize, creating a stable clot.
How much plasma do you get from 10ml blood?
Depending on the hematocrit of the patient, one 10 mL tube of blood yields 3 to 5 aliquots of plasma in volumes of 1 mL per vials. The average yield from 10 mL blood collection is a total of 4 mL of plasma.
What is plasma concentration in pharmacokinetics?
“Drug concentration” is derived by collecting a blood sample at any time after drug administration and measuring the amount of a drug in a given volume of blood plasma of the sample. 8. The measured drug concentration is generally known as “plasma concentration.”
What is the difference between plasma and serum quizlet?
What is the difference between serum and plasma quizlet microbiology?
How does plasma concentration affect medication actions?
As the con- centration of drug in plasma increases, the concentration of drug in most tissues will increase proportionally. Similarly, if the plasma concentration of a drug is decreasing, the concentration in tissues will also decrease.
What is the major difference between serum and plasma quizlet?
How much of blood is serum?
Serum is plasma without the clotting factors. Red blood cells account for approximately 45% of the whole blood, white blood cells and platelets approximately 1%, and serum or plasma accounts for the remainder, approximately 55% of the volume (Fig. 3).
What does increased serum concentration mean?
Your doctor may test your serum blood levels for sodium, magnesium, cholesterol and other important levels that may indicate changes in your blood profile. Serum blood levels showing increased levels of these markers may spell an increased risk for chronic medical conditions or psychotic episodes.